You should get more exposure that way. Your listing will be at the top of a search results page. That's the only plus I see.
I rarely, if ever see the items listed on the actual home page as they are off the screen past the bottom. In fact, my desktop icon takes me right to 'My eBay'.
Your item needs to be common (lots of them on eBay and people searching for it) and rare (something about it makes it special and better than most)... Does that make any sense? I guess the rare is less important.
For example, this would have been a great idea for your guitar. There were lots of guitars, but few with its heritage.
Good Luck either way you go!